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New molecular experiments have presented quite a few insights into your processes that govern the development and development of CLL, like many novel mutated genes clustered in several functional pathways. The CLL epigenome is reprogrammed from the modulation of regulatory areas that appear de novo
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Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.
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